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This remains a hypothesis, but the overlap between GLP-1 signaling and inflammatory pathways is biologically compelling

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In some studies, dietary levels of LA have been reported to associate with observed octadecanoid levels, for example, increased dietary LA resulted in higher observed LA-derived octadecanoid levels in the brain, 115 while lowering dietary LA resulted in lower plasma levels of 9- and 13-HODE (as well as 9- and 13-oxo-ODE)